Researchers from National Institute of Technology (NIT), Rourkela have developed and patented a bio-ink designed for use in 3D bioprinting of tissue-like structures, according to a recent study.
Bio-inks are materials used in 3D bioprinting to create structures that mimic biological tissues. The research team reported that their formulation combines mechanical strength, biological compatibility and printability, which are key challenges in the field.
The study, published in the peer-reviewed journal International Journal of Biological Macromolecules, describes a protein–polysaccharide-based bio-ink developed using bovine serum albumin, sodium alginate, and polyelectrolyte complexes of gelatin and chitosan.
According to the researchers, the material demonstrated high shape fidelity and supported cell growth in laboratory conditions. Experiments showed that scaffolds prepared using the bio-ink achieved over 90 per cent cell viability and exhibited properties associated with bone tissue, including support for cell adhesion and proliferation.
The technology has also been granted a patent titled “A High Shape-Fidelity Protein-Polysaccharide Composite Bioink for 3D Bioprinting” (Patent No. 583759; Application No. 202431019470).
Commenting on the work, Prof Devendra Verma, Associate Professor at NIT Rourkela, said the aim was to address limitations in existing bio-inks by improving both structural and biological performance. Research scholar Shreya Chrungoo stated that the material could serve as a platform for developing customised scaffolds in tissue engineering.
While the findings indicate potential applications in areas such as bone and cartilage tissue engineering, the study is limited to laboratory-scale experiments. The research team stated that further studies, including animal trials, are planned to evaluate safety and effectiveness.
